for  the  use only      of registered medical practitioners or a hospital or a laboratory.

Clinical trial with ALOES COMPOUND" & MYRON*

in cases of bovine infertility

paper presented at: First Asian Congress of Fertility & Sterility (Animal Reproduction Session) Bombay, 19-23 February 1977

Organized by: Indian Association of Fertility & Sterility.

Patronized by :                   International Federation         of Fertility Societies.

Dr. B, N. Dange, MVSc., (Animal Reproduction) Veterinary Poly Clinic, Kolhapur, Maharashtra.

SUMMARY

Reproductive disturbances, resulting in delayed conception and intercalving period are a serious drain on resources of farmers. ALOES COMPOUND Ft MYRON 2 Alarsin Ayurvedic research products were tried in 26 imported cross bred cows, 21 cross bred heifers and 30 local buffaloes, if various reproductive disturbances, both pathological and non-pathological.

 

OVERALL

GROUP

CONCEPTION

HEIFERS

RATE

COWS

BUFFALOES

MEAN

Pathological Group

Non-Pathological Group :

100%

100%

86%

80%

80%

89%

85%

Total Mean :

l00'/Q

83%

78%

87%

 

INTRODUCTION


Milk production in India is largely organized on industrial grounds. Milk cattle are kept by farmers, even by small and marginal agri­cultural labourers.  Due to prevailing socio economic conditions, they are usually unawar of various physiological and pathological condi­tions leading to infertility.

 

In Maharashtra, interest in dairy husbandry is picking up because of assured remunerative prices without discriminating cow and buffalo milk. There has been a search in keeping cross bred cows as against the traditional practice of keeping buffaloes for milk production. Particularly in Kolhapur District, there has been large scale importation of cross bred cows, purchased at and around Bangalore.

Details of pedigree record or past clinical records are rarely available either with the owner who sells the cow or the farmers who purchases the same. Most of the purchases have been made through Bank finances

Reproductive disturbances due to pathogenic conditions resulting in delayed conception and long intercalving period proved as serious drain on the resources of farmers. Usual line of treatment for such cases is with local applications of lugol, and antibiotics. But results are rather low and not definite and treatment is a long drawn affair. An attempt was therefore made to treat such types of cases with Myron and Aloes Compound­

 

MATERIALS AND METHODS

A total of 26 imported cross bred cows, 21 cross bred heifers and 30 local buffaloes were presented for treatment at the Veterinery Poly Clinic, Kolhapur, with complaints of repeat breeding, de layed post partum heats etc. The details of the animals are as under

TABLE No. 1- Showing the complaints

 

 

Heifers

Cows

Buffaloes

1. Irregular oestrus

 

 

 

2. Suboestrus (Weak/Silent Heat)

 

3

 

3. Anoestrus

 

 

 

4. Atonic Reproductive tract

 

2

 

5. Pathological conditions (endometritis,

 

 

 

Metritis, Paramc-tiritis etc.)

6

21

15

Total :

21

26

30

 

ALOES COMPOUND

The drug is backed with a number of clinical and pharmacological trials in laboratory animals and human beings        The drug is indicated to induce regular Menstrual/ovulatory cycles. It is non-hormonal Ayurvedic combination which in addition to above action is also having haematinic, liver corrective, nerve soothing and mild laxative actions without harmful side effects. It is also stated to be useful to reduce obesity. Aloes Compound was chosen for trial in non­pathogenic, suboestrus and irregular oestrous in cows and buffaloes and in heifers who suffered from environmental conditions and substandard feeding.

 

MYRON:

This drug is claimed to be very useful in treat­ment of non-specific leucorrhoea, and specific leucorrhoea due to cervicitis, endometritis, cervical erosious, moniial and Trichomonas infections in human beings in a number of trials It is said to have uterine antiseptic, ecbolic, anti­bacterial, anti-inflammatory and analgesic pro­perties and useful as haematinic and general tonic also.

 

Aloes Compound was selected for treatment of non pathogenic condition such as suboestrus, anoestrus, and atonic reproductive tract. Each case was treated with 5 tablcts a day over a period of one to two oestrus cycles (20 to 48 days). The animals were inseminated when the first oestrus was exhibited and detected. The treatment was continued for another three weeks when only weak and silent heats were noticed. A course of 10 tablets daily over a period of 10 days was used, (however there was some incidence of post oestrus bleeding, particularly in heifers; and hence dose was reduced to 5 tablets a day for three weeks in such cases) .

 

Myron was used in pathogenic conditions at lie rate of 10 tablets a day ovcr a period upto 20 days or until the oestrual discharge became normal. Subsequently these cases were treated with 5 tablets of Myron and 5 tablets of Aloes Compound over a period of 20 days to stimulate reproductive tract and ensure ovulation and conception.

RESULTS

 

Out of 21 cross bred heifers all conceived. Out of 26 cross bred cows, 22 conceived within the expected time and remaining 4 conceived subsequently. Out of 30 buffaloes, 17 out of 22 followed up, conceived. Remaining eight could not be followed-up due to change of ownership.

 

TABLE NO. 2 -RESULTS

Pathogenic cases treated and conceived in Trial Period:

 

 

ANIMALS

NO. OF CASES TREATED

NO. OF CASES CONCEIVED

CASES NOT FOLLOWED

% OF

CONCEPTION


Heifers                      6                                  6                      -                       100%


Cows                       21                                 18                    -                       86%

Buffaloes             10+(5)                     8                  5                  80%

TABLB NO. 3 - RESULTS

Non-Pathogenic cases treated and conceived in Trial Period :

 

ANIMALS

NO. OF CASES TREATED

NO. OF CASES CONCEIVED

CASES NOT FOLLOWED

% OF

CONCEPTION

Heifers

15

15

-

100%

Cows

5

4

-

80%

Buffaloes

12+3

9

3

75%
OVERALL CONCEPTION RATES

 

GROUP

 

HEIFERS

RATE

COWS

BUFFALOES

MEAN

 

Pathological Group

Non-Pathological Group :

100%

100%

86%

80%

80%

75%

89%

87%

 

Total Mean :

100%

83%

78%

87%

 

DISCUSSION :                                            

It was noticed that use of Aloes Compound following results :

i)                    Tones up the uterus.

ii)                  Ensures oe3trus at regular intervals of 18 to 22 days,

iii)                 Increases the chances of fertilization of ovum

iv)                Ensures pronounced heat symptoms thereby reduces difficulties in detecting weak and silent heat particularly in buffaloes

v)                 Reduces puberty age and maturity in heifers. It was noticed that treated heifers exhibited their first oestrus at the end of the treatment period,

Similarly Myron was useful in the treatment of resistant & Chronic pathological condition of resistant  and cronic pathological condition of infectious origin and was found to be useful in cleaning & toning up the uterus and thereby ensuring the regular heat and conception.

ACKNOWLEDGEMENT

My sincere thanks are due to:

1.  Dr. V, M. Kotbagi, Director of Animal Hubandry, Maharashtra State, Poona, for his inspration to me in carrying out this study trial and allowing me for publication of the same,

2,  Dr. Tatakc, Technical Officer, for his valuable guidance in this study,

3. Research Division of Alarsin Pharmaceuticals, Bombay, India, for kind co-ordination and encouragement.

REFERENCES

l,   Mrs, Bulsara Rohan R, R, (1966) :   Sterility associated with irregular and scanty menstruation (Use of Aloes Compound as an adjuvant) : The Indian Pract., 19 :1-123-5 Jan.

2.  Mukerjee Gauri & Mukerjee Krishna (1974) : Clinical trial with Myron in Non-specific Leucorrhoea in Rural population ; Current Med. Pract. Vol. 18, No, S, 345-346, Aug.

3.  Murlidhar Rao, K. (1976) : Leucorrhoea and its treatment with an indigenous drug Myron : Mediscope, Vol. XIX,

No. VI, Sept.,

4.  Rajasekharan, N-Vijaya, R., Celia Dorothy White & Uma Rani, S. (1975) ; Trial with the indigenous drug Aloes Compound in Infertility - The Antiseptic, Vol. 72, No. 9, pp. 451-457, Sept.

S. Ramani Sivaraman. Sujaya Kumari and Usha Kannan (1976) Aloes Compound in Sterility - The Antiseptic, Vol. 73, No. 7, July, (pp. 366-370).

b.  Sharma, S. C., Chadha, M. & Burjorjec, M. N. (1972) - The effect of Aloes Indiea on the Fertility of female Rebbits paper at XVI All India obst, M. Gynec. Congress, New Delhi, 10-12, March 1972.

7, Salisbury, C. W. M, Vass N. t,. : Physiology of Reproduction & Artificial Insemination of Cattle, Denmark, P-480-51,

S S/8/85